Preclinical Oncology Services
Despite decades of active research, cancer remains the most common cause of human deaths especially in developed countries. Hundreds of billions of dollars have been invested in cancer research and development of anti-cancer therapies. Expensive failures of potential blockbuster drugs in clinical trial stage force pharmaceutical companies to pay more attention to preclinical drug development.
More intensive preclinical studies will help you better understand pharmacological mechanism, ease drug safety concerns, evaluate drug efficacy, thereby increasing the success rate in late stages. GenScript offers comprehensive preclinical oncology services as your single solution of anti-cancer drug development. The preclinical oncology services range from high throughput screening (HTS) against pharmacological targets or tumor cell lines to in vitro and in vivo drug efficacy evaluation. |
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| ADCC and CDC Assay Services
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Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are major antibody-based mechanisms of immune defense system. The ADCC and CDC activities are always the most important criteria to evaluate the antibody efficacy on the drug target. |
| Growth Inhibition Assay Services
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To meet various demands for tumor growth inhibition assay services, GenScript has developed conventional and novel HTS compatible growth inhibition assays based on MTT/SRB/LDH method and Promega’s CellTiter-Glo® luminescent cell viability assay kit respectively.
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| Apoptosis Assay Services
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To offer reliable apoptosis results, GenScript has developed a series of apoptosis assays based on individual method: TUNEL Assay, Annexin V Assay, Mitochondrial Apoptosis Assay (JC-1), and Caspase Assay.
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| In Vivo Drug Efficacy Evaluation Services
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With ample expertise in animal experiments, GenScript has developed 30+ ready human tumor xenograft models and syngeneic mouse tumor models to offer comprehensive preclinical oncology services. For more animal models of your interests, GenScript also offers custom animal model services tailored to your special requirement.
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| Human Tumor Cell Line Panel
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GenScript collected some 250 human tumor cell lines covering all common cancer types from ATCC and DSMZ. Based on the human tumor cell line panel, GenScript offers comprehensive in vitro tumor cell line profiling and in vivo drug efficacy evaluation services to boost your anticancer drug discovery.
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Biochemical Assay Services:
 Kinase Assay Services
Protease Assay Services
Miscellaneous Enzymes Assay Services
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Email: bioassay@genscript.com |
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Phone: 1-877-436-7274 (Toll-Free), 1-732-885-9188 |
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Fax: 1-732-210-0262, 1-732-885-5878 |
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